DrugTech Research Community Seminar

Welcome to a seminar series´ webinar organized by the multi-disciplinary research community Drug Discovery and Delivery (DrugTech) at the University of Eastern Finland.

Professor Doctor Tessa Lühmann, Institute of Pharmacy and Food Chemistry, Pharmaceutics and Food technology, University of Würzburg, Germany, will give a talk on the title Molecular design of bioconjugates.

Welcome and concluding remarks by Chairman, Professor Arto Urtti, School of Pharmacy, University of Eastern Finland. No registration required. The event will be recorded. In participating in the seminar, you automatically agree to the recording.

Research Interests

Motivated by a specific interest in regenerative medicine, our research activities focus on the design of engineered therapeutic proteins to develop bioresponsive drug release systems, releasing drugs as a result of an external, biochemical stimulus in diseased tissues. In the field of protein formulation, we explore novel and innovative methods to gain further insights into protein stability and sites of modification at the molecular level.

Methods and Techniques

Recombinant, synthetic and semi-synthetic peptide and protein synthesis, genetic code expansion, site-specific protein modification, bioorthogonal chemistries, PEGylation, PEG alternative polymers, bioresponsive drug delivery, mass spectrometry

Curriculum Vitae

Since 2021    Professor for Pharmaceutics and Food Technology, University of Würzburg, Germany

2013-2017     Habilitation, Faculty of Chemistry and Pharmacy, University of Würzburg

2013               Research Scholar, Prof. Bradley Pentelute, Department of Chemistry, MIT, Cambridge, USA

Since 2011    Research Group Leader, Institute of Pharmacy, Chair of Pharmaceutics and Biopharmacy, University of Würzburg

2009-2010     Postdoctoral work with Prof. Viola Vogel and Prof. Bradley Nelson, ETH Zürich

2006-2009    PhD with Prof. Viola Vogel, ETH Zürich, Switzerland

2001-2006     Studies of biochemistry (University of Leipzig and ETH Zürich), Diploma thesis with Prof. Annette Beck-Sickinger (University of Leipzig, Germany)

Key Publications

V. Spieler et al., J. Control. Release, 2020, 326, 10, 172-180,Targeting interleukin-4 to the arthritic joint. DOI: doi.org/10.1016/j.jconrel.2020.07.005 

S. Sevim et. al., ACS Biomater. Sci. Eng. 2017, 3(6), 1000–1007, Nanomechanics on FGF-2 and heparin reveal slip bond characteristics with pH dependency
DOI: 10.1021/acsbiomaterials.6b00723

J. Ritzer, T. Lühmann et. al., Nat. Commun. 2017, 8 (1), 264, Diagnosing peri-implant disease using the tongue as a 24/7 detector
DOI:  10.1038/s41467-017-00340-x