Metabolic Diseases

Cardiometabolic diseases encompass a spectrum of disorders that affect the cardiovascular and metabolic systems, leading to conditions such as diabetes, obesity, and cardiovascular diseases. These diseases are characterised by a complex interplay of genetic, environmental, and lifestyle factors, making them a significant global health concern. However, recent advancements in the field are expected to lead to precision medicine and personalised treatment options. 

The Metabolic Diseases research community (RC) is dedicated to developing novel, innovative solutions for the management of cardiometabolic diseases. Our research relies on genetics and genomics to explore the pathological mechanisms and gene-lifestyle interactions underlying these conditions. Nutrition and exercise interventions complement our studies. Through these concerted efforts, we build the framework for early identification, prevention, and personalised treatment of individuals at increased risk of cardiometabolic diseases and their complications. Ultimately, our goal is to enhance public health awareness and improve the cost-effectiveness of healthcare throughout the life cycle.

Multi-omics guided personalised cardiometabolic health

Integrating genomics, transcriptomics, proteomics, and metabolomics data provides insights into the pathophysiological mechanisms and genetic background of cardiometabolic diseases. Candidate genes linked to these conditions are identified and validated using cell lines, animal models, and patient samples, deepening our understanding of disease susceptibility and progression. Novel algorithms are developed to extract meaningful data.

Enhancing cardiometabolic health through lifestyle interventions

We investigate how diet, physical activity, and lifestyle impact cardiometabolic health through long-term intervention studies. Novel biomarkers are identified for cardiometabolic health. Gene-diet interactions are explored to develop personalised recommendations based on genetic profiles, addressing individual variations in nutrient metabolism and dietary needs. 

Supporting techniques and expertise in cardiometabolic research

The continuous advancement of technologies in metabolomics and genetics is essential for understanding cardiometabolic diseases. These developments, combined with bioinformatics and advanced computational tools, collectively improve strategies for the prevention, diagnosis, and treatment of cardiometabolic health. Likewise, specialised knowledge such as mitochondrial biology is needed to understand cell function and disorders.